Unraveling Signalling Dynamics of CD24 in B Lymphocytes
Monday, Jan. 19, 1-2 p.m.
CSF-1302
Hello Everyone,
You are warmly invited to attend the upcoming seminar on Monday, January 19th , 2026. Please find the details below.
Unraveling Signalling Dynamics of CD24 in B Lymphocytes
Kaitlyn Mayne
PhD Student
Department of Human Biosciences
January 19th, 2026
1:00 p.m. – 2:00 p.m.
CSF-1302
The direct link for the meeting is:
https://mun.webex.com/mun/j.php?MTID=m80d15116e3eeb31ee73052c60e557171
Abstract
CD24 is a GPI-anchored protein that shapes early B‑cell maturation and regulates apoptosis and extracellular vesicle (EV) release. Since CD24 lacks a cytosolic signalling domain, it requires a signalling partner with the necessary machinery to modulate intracellular signals. In other cell types, Siglecs have been found to interact with CD24. However, the signaling partner of CD24 in B cells remains unknown.
Additionally, activation of CD24 has been shown to trigger a novel signalling cascade (aSMase/PI3K/mTORC2/ROCK/actin) which regulates the packaging of ectosomes. Ectosomes are plasma membrane-derived vesicles, typically 100-1000 nm in diameter. The exact mechanisms of ectosome packaging, secretion, and trafficking in B cells are poorly understood.
Overall, this project aims to identify the required signalling partner of CD24 for downstream signalling of apoptosis and EV release, to understand the mechanism of CD24-activated EV formation, and to characterize the functional ectosome populations regulated by CD24 signalling.
All are welcome to attend. Please mark your calendars and join us for this exciting presentation.
Best regards,
Presented by Department of Human Biosciences