BioMedical Sciences Research Forum
Wednesday, March 8, 12-1 p.m.
HSC-5M101 and online
Dr. Janna Andronowski
THE USE OF HIGH-RESOLUTION 3D IMAGING, HISTOLOGY, AND ANIMAL MODELS TO UNDERSTAND OPIOID-RELATED BONE TISSUE CHANGES
Research in the Andronowski Lab focuses on the high-resolution 3D imaging of bone microarchitecture and the study of bone adaptation, quality, and fragility associated with substance abuse. The bone remodeling process underlies pathological changes, and thus the spatial distribution, orientation, and size of the products of remodeling (e.g., pores within cortical bone) are believed to carry mechanical and/or physiological significance. Limited data exist, however, related to the impact of opioid use on human cortical bone remodeling from modern forensic autopsy cases and in preclinical animal models. Visualization and analysis of bone in 3D hold the potential to improve our understanding of opioid-induced bone pathology and hone related clinical and forensic anthropological applications. This scale of analysis allows for two related research objectives to be addressed to: 1) identify pathological changes to cortical bone microstructure with prolonged opioid use, and 2) quantify and model morphometric differences in vascular pore systems and bone’s cellular organization (e.g., osteocyte lacunar parameters) between control and drug treatment groups. This seminar highlights interdisciplinary efforts focused on both improving forensic skeletal identification methods and identifying suitable time frames for pharmaceutical intervention for the treatment of opioid-induced osteoporotic-like bone loss.
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Presented by Division of BioMedical Sciences