BioMedical Sciences Research Forum
Wednesday, May 10, 12-1 p.m.
DEEPAK KAUSHIK, PHD
ASSISTANT PROFESSOR, IMMUNOLOGY
INVESTIGATING NOVEL IMMUNOMETABOLIC MARKERS
TO STUDY IMMUNE FUNCTIONS IN MULTIPLE SCLEROSIS
Multiple sclerosis (MS) is a highly inflammatory, demyelinating, and degenerative condition of the central nervous system (CNS). Due to its high prevalence within the country, MS is often referred to as “Canada’s disease”. Immune cells including Tcells, B- cells, macrophages and microglia (brain resident macrophages), among others, play important roles in the manifestation and progression of MS. ‘Immunometabolism’ is a newer discipline of Immunology which focuses on understanding the metabolic needs (energy requirements) of immune cells as they execute their functions. Kaushik Lab focuses on understanding the role of different metabolic pathways that guide monocyte/macrophages and microglia to dictate neuroinflammation during MS pathogenesis. Using primary cell cultures and transgenic mouse models, and high throughput techniques such as scRNA-seq, Dr. Kaushik has unravelled important roles for a novel immunometabolic player, extracellular matrix metalloproteinase inducer (EMMPRIN), in the manifestation of MS pathogenesis. For his talk at the BMS Research Forum, he will review the basics of immunometabolism, and discuss some of the observations from an ongoing work in his lab.
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Presented by Division of BioMedical Sciences