LDL Transcytosis Across the Arterial Endothelium: How Atherosclerosis Begins
Monday, Feb. 9, 1-2 p.m.
CSF-1302
Hello Everyone,
You are warmly invited to attend the upcoming seminar on Monday, February 9th, 2026. Please find the details below.
February 9th, 2026
1:00 p.m. – 2:00 p.m.
CSF-1302
The direct link for the meeting is:
https://mun.webex.com/mun/j.php?MTID=m40e70b840248f26ba9cf7123cea14eac
Speaker: Dr. Warren Lee (M.D., Ph.D. ,Department of Medicine, University of Toronto)
Title: LDL transcytosis across the arterial endothelium – how atherosclerosis begins
Abstract:
Atherosclerosis begins as early as the first decade of life with the accumulation of low density lipoprotein (LDL) cholesterol under the endothelial layer that lines arteries. This leads to the development of plaque in the coronary arteries and can manifest decades later as a heart attack. How circulating LDL is able to cross the endothelium has been one of the longstanding controversies in cardiovascular medicine. Dr. Lee’s lab was the first to show that LDL passes through individual endothelial cells by a receptor-mediated process known as transcytosis. Multiple studies have now shown that inhibition of LDL transcytosis attenuates both early and advanced atherosclerosis, making it a new therapeutic target for the prevention or treatment of heart disease. In his talk, Dr. Lee will review the evidence implicating LDL transcytosis in atherogenesis and will highlight new discoveries about its regulation.
All are welcome to attend. Please mark your calendars and join us for this exciting presentation.
Best regards,
Presented by Department of Human Biosciences