Liver Gene Editing: Basic Science Applications and Translational Challenges

Monday, Oct. 6, 1-2 p.m.

CSF-1302

Genome editing with CRISPR/Cas9 has revolutionized both basic science research as well as human therapeutics. The liver is a particularly attractive target that serves as a central metabolic hub for the rest of the body. Both viral and non-viral delivery systems have been used to make permanent genetic changes in hepatocytes. This seminar will illustrate the utility of liver-directed genome editing as a tool for basic science in model organisms. It will also cover our work on improving the efficiency of gene editing, with an eye towards therapeutic development for lipid disorders.

Presented by Dr. William Lagor, Baylor College of Medicine

Event Listing 2025-10-06 13:00:00 2025-10-06 14:00:00 America/St_Johns Liver Gene Editing: Basic Science Applications and Translational Challenges Genome editing with CRISPR/Cas9 has revolutionized both basic science research as well as human therapeutics. The liver is a particularly attractive target that serves as a central metabolic hub for the rest of the body. Both viral and non-viral delivery systems have been used to make permanent genetic changes in hepatocytes. This seminar will illustrate the utility of liver-directed genome editing as a tool for basic science in model organisms. It will also cover our work on improving the efficiency of gene editing, with an eye towards therapeutic development for lipid disorders. CSF-1302 Dr. William Lagor, Baylor College of Medicine