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Medical Genetics and Cancer and Development Seminar Series

Monday, Nov. 21, 12-1:30 p.m.

HSC-5M101; online

Shamila Yazdanpanah, MSc Candidate

Dr. Leitges’ Laboratory

“PKCε switches Aurora B specificity to exit the abscission checkpoint”

Objectives:

1. Better understanding of abscission signaling pathways and its importance in medical and cancer research.

2. Providing novel insights into actions of major protein kinases, Aurora B and PKCε, in abscission checkpoint.

 

Roumina Rouhani Ardeshiri, MSc Candidate

Dr. Leitges’ Laboratory

“The Aurora B specificity switch is required to protect from nondisjunction at the metaphase/anaphase transition”

Objectives:

1. Defining a mechanism by which the key mitotic kinase, Aurora B orchestrates safe passage through the metaphase-anaphase transition in the presence of mitotic catenation.

2. Identifying the TopoIIα S29 phosphorylation as being necessary for enhanced catenation resolution.

3. Investigating the input upstream of Aurora B which involves a non-canonical Caspase-7 signalling pathway resulting in the proteolytic cleavage of PKCε in mitosis.

Webex details: please contact Barbara Hynes at bjhynes@mun.ca

Presented by Division of BioMedical Sciences

Event Listing 2022-11-21 12:00:00 2022-11-21 13:30:00 America/St_Johns Medical Genetics and Cancer and Development Seminar Series Shamila Yazdanpanah, MSc Candidate Dr. Leitges’ Laboratory “PKCε switches Aurora B specificity to exit the abscission checkpoint” Objectives: 1. Better understanding of abscission signaling pathways and its importance in medical and cancer research. 2. Providing novel insights into actions of major protein kinases, Aurora B and PKCε, in abscission checkpoint.   Roumina Rouhani Ardeshiri, MSc Candidate Dr. Leitges’ Laboratory “The Aurora B specificity switch is required to protect from nondisjunction at the metaphase/anaphase transition” Objectives: 1. Defining a mechanism by which the key mitotic kinase, Aurora B orchestrates safe passage through the metaphase-anaphase transition in the presence of mitotic catenation. 2. Identifying the TopoIIα S29 phosphorylation as being necessary for enhanced catenation resolution. 3. Investigating the input upstream of Aurora B which involves a non-canonical Caspase-7 signalling pathway resulting in the proteolytic cleavage of PKCε in mitosis. Webex details: please contact Barbara Hynes at bjhynes@mun.ca HSC-5M101; online Division of BioMedical Sciences